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CEP-28122 mesylate

CAS No. ——

CEP-28122 mesylate( —— )

Catalog No. M16991 CAS No. ——

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CEP-28122 mesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
  • Description
    A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    ALK
  • Recptor
    ALK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    635.1746
  • Molecular Formula
    C29H39ClN6O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 6.4 mg/mL; DMSO < 9.2 mg/mL
  • SMILES
    ——
  • Chemical Name
    Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9. 2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
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